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Canagliflozin

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Cat.No：IC1610 Solarbio

CAS：842133-18-0

Molecular Formula：C₂₄H₂₅FO₅S

Molecular Weight：444.52

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	842133-18-0
Name	Canagliflozin
Molecular Formula	C₂₄H₂₅FO₅S
Molecular Weight	444.52
Solubility	Soluble in DMSO ≥80mg/mL
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 695-192-1
MDL	MFCD18251436
SMILES	FC1=CC=C(C2=CC=C(CC3=C(C=CC([C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C3)C)S2)C=C1
InChIKey	XTNGUQKDFGDXSJ-ZXGKGEBGSA-N
InChI	InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1
PubChem CID	24812758
Target Point	mSGLT2;rSGLT2;hSGLT2
Passage	Membrane Transporter&Ion Channel
Background	Canagliflozin is a selective SGLT2 inhibitor.
Biological Activity	Canagliflozin是选择性的 SGLT2 抑制剂，在mSGLT2，rSGLT2和hSGLT2细胞中的IC50分别为2 nM，3.7 nM和4.4 nM[1]。
Data Literature Source	[1]. Liang Y，et al. Effect of canagliflozin on renal threshold for glucose，glycemia，and body weight in normal and diabetic animal models. PLoS One. 2012;7(2):e30555. [2]. Kobuchi S，et al. A validated LC-MS/MS method for the determination of canagliflozin，a sodium-glucose co-transporter 2 (SGLT-2) inhibitor，in a lower volume of rat plasma: application to pharmacokinetic studies in rats. Biomed Chromatogr. 2016 Oct;30(10):1549-55.
Unit	Piece
Specification	5mg 10mM*1mL in DMSO 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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