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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > BMS-754807CAS：1001350-96-4
Molecular Formula：C23H24FN9O
Molecular Weight：461.49
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1001350-96-4 |
| Name | BMS-754807 |
| Molecular Formula | C23H24FN9O |
| Molecular Weight | 461.49 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18633202 |
| SMILES | FC1=CC=C(NC([C@@]2(C)N(C(N=C3NC4=NNC(C5CC5)=C4)=NN6C3=CC=C6)CCC2)=O)C=N1 |
| InChIKey | LQVXSNNAFNGRAH-QHCPKHFHSA-N |
| InChI | InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m0/s1 |
| PubChem CID | 24785538 |
| Target Point | IGF-1R inhibitor |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | BMS-754807 is a potent, reversible insulin-like growth factor 1 receptor/insulin receptor inhibitor. |
| Biological Activity | BMS-754807 是有效、可逆的胰岛素样生长因子1受体/胰岛素受体抑制剂，其 IC50 值分别为 1.8 和 1.7 nM，Ki 值均小于 2 nM；同时也抑制 Met，RON，TrkA，TrkB，AurA 和 AurB 的活性，其IC50 值分别为 6，44，7，4，9和 25 nM[1-4]。 |
| Data Literature Source | [1]. Carboni JM，et al. BMS-754807，a small molecule inhibitor of insulin-like growth factor-1R/IR. Mol Cancer Ther，2009，8(12)，3341-3349. [2]. Wittman MD，et al. Discovery of a 2，4-disubstituted pyrrolo[1，2-f][1，2，4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development. J Med Chem，2009，52(23)，7360-7363. [3]. Kolb EA，et al. Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program. Pediatr Blood Cancer，2011，56(4)，595-603. [4]. Franks SE，et al. BMS-754807 is cytotoxic to non-small cell lung cancer cells and enhances the effects of platinum chemotherapeutics in the human lung cancer cell line A549. BMC Res Notes. 2016 Mar 1;9:134. |
| Unit | Piece |
| Specification | 2mg 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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