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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > BestatinCAS：58970-76-6
Molecular Formula：C16H24N2O4
Molecular Weight：308.37
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 58970-76-6 |
| Name | Bestatin |
| Molecular Formula | C16H24N2O4 |
| Molecular Weight | 308.37 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 261-529-2 |
| MDL | MFCD00083262 |
| SMILES | CC(C)C[C@@H](C(O)=O)NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O |
| InChIKey | VGGGPCQERPFHOB-RDBSUJKOSA-N |
| InChI | InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 |
| PubChem CID | 72172 |
| Target Point | Aminopeptidase |
| Passage | Metabolic Enzyme&Protease |
| Background | Bestatin is a broad-spectrum, competitive aminopeptidase inhibitor. |
| Biological Activity | Bestatin是一种广谱，竞争性的氨肽酶抑制剂[1-4]。 |
| Data Literature Source | [1]. Hossain A，et al. Protective effects of bestatin in the retina of streptozotocin-induced diabetic mice. Exp Eye Res. 2016 Aug;149:100-6 [2]. Qian X，et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2016 May-Jun;23(3):e680-9. [3]. Lis M，et al. The effects of bestatin on humoral response to sheep erythrocytes in non-treated and cyclophosphamide-immunocompromised mice. Immunopharmacol Immunotoxicol. 2013 Feb;35(1):133-8 [4]. Poloz Y，et al. Bestatin inhibits cell growth，cell division，and spore cell differentiation in Dictyostelium discoideum. Eukaryot Cell. 2012 Apr;11(4):545-57 |
| Unit | Piece |
| Specification | 10mg 20mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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CoCl 2 increases the expression of hypoxic markers HIF-1α, VEGF and CXCR4 in breast cancer MCF-7 cells
Click to check >>Author：Li Q , Ma R , Zhang M .
IF：2.7850
Publish_to：Oncol Lett.
PMID：29391899
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