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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > BAY 11-7082CAS：19542-67-7
Molecular Formula：C10H9NO2S
Molecular Weight：207.25
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 19542-67-7 |
| Name | BAY 11-7082 |
| Molecular Formula | C10H9NO2S |
| Molecular Weight | 207.25 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00712162 |
| SMILES | N#C/C=C/S(=O)(C1=CC=C(C)C=C1)=O |
| InChIKey | DOEWDSDBFRHVAP-KRXBUXKQSA-N |
| InChI | InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+ |
| PubChem CID | 5353431 |
| Target Point | NF-kB |
| Passage | NF-κB |
| Background | BAY 11-7082 is an inhibitor of IκBα phosphorylation and NF-κB that selectively and irreversibly inhibits TNF-α-induced phosphorylation of IκB-α and reduces expression of NF-κB and adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific proteases USP7 and USP21. |
| Biological Activity | BAY 11-7082是 NF-κB 抑制剂， 其通过抑制TNF-α诱导的IκB-α磷酸化来降低NF-κB。 BAY 11-7082抑制泛素化蛋白酶 USP7 和 USP21 的 IC50 分别为0.19 μM 和 0.96 μM[1-4]。 |
| IC50 | USP7:0.19μM;USP21:0.96μM [1-4] |
| Data Literature Source | [1]. Mori N，et al. Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines andprimary adult T-cell leukemia cells. Blood. 2002 Sep 1;100(5):1828-1834. [2]. Ritorto MS，et al. Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. Nat Commun. 2014 Aug 27;5:4763. [3]. Strickson S，et al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem J. 2013 May 1;451(3):427-437. [4]. Pierce JW，et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997 Aug 22;272(34):21096-103. |
| Unit | Piece |
| Specification | 5mg 10mM*1mL in DMSO 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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