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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > DiosmetinCAS：520-34-3
Molecular Formula：C16H12O6
Molecular Weight：300.26
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 520-34-3 |
| Name | Diosmetin |
| Molecular Formula | C16H12O6 |
| Molecular Weight | 300.26 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-291-8 |
| MDL | MFCD00017425 |
| SMILES | O=C1C=C(C2=CC=C(OC)C(O)=C2)OC3=CC(O)=CC(O)=C13 |
| Target Point | Cytochrome P450 |
| Passage | Metabolic Enzyme&Protease |
| Background | Diosmetin is an agonist of the aryl hydrocarbon receptor (AHR). |
| Biological Activity | Diosmetin是抑制人CYP1A酶活性的天然类黄酮, 在HepG2细胞的 IC50值为40 μM[1]。 |
| IC50 | 40μM(Others，HepG2 cell)[1] |
| Data Literature Source | [1]. Liu B，et al. Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells. Mol Med Rep. 2016 Jul;14(1):159-64. [2]. Yu G，et al. Diosmetin ameliorates the severity of cerulein-induced acute pancreatitis in mice by inhibiting the activation of the nuclear factor-κB. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2133-42. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Profiling of phenolic acids and flavonoids in sweet potato (Ipomoea batatas L.) leaves and evaluation of their anti-oxidant and hypoglycemic activities
Click to check >>Author：D Luo; Mu T ; Sun H .
IF：4.3050
Publish_to：[J]. Food Bioscience
PMID：
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