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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > AZD-1480CAS：935666-88-9
Molecular Formula：C14H14ClFN8
Molecular Weight：348.77
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
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| CAS | 935666-88-9 |
| Name | AZD-1480 |
| Molecular Formula | C14H14ClFN8 |
| Molecular Weight | 348.77 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| MDL | MFCD16038904 |
| SMILES | ClC1=C(N=C(N=C1)N[C@@H](C)C2=NC=C(C=N2)F)NC3=NNC(C)=C3 |
| InChIKey | PDOQBOJDRPLBQU-QMMMGPOBSA-N |
| InChI | InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 |
| PubChem CID | 16659841 |
| Target Point | JAK |
| Passage | JAK/STAT Signaling |
| Background | AZD-1480 is a novel ATP-competitive inhibitor of JAK2 |
| Biological Activity | AZD-1480 是一种新颖的 JAK2 的ATP竞争性抑制剂，IC50 值为 < 0.4 nM[1-6]。 |
| IC50 | JAK1:1.3nM;JAK2:0.4nM [1-6] |
| Data Literature Source | [1]. Derenzini E，et al. The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma. Blood Cancer J. 2011 Dec;1(12):e46. [2]. Scuto A，et al. The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling，resulting in suppression of human myeloma cell growth and survival. Leukemia. 2011 Mar;25(3):538-50. [3]. McFarland BC，et al. Therapeutic potential of AZD1480 for the treatment of human glioblastoma. Mol Cancer Ther. 2011 Dec;10(12):2384-93. [4]. Xin H，et al. Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. Cancer Res. 2011 Nov 1;71(21):6601-10. [5]. Hedvat M，et al. The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell. 2009 Dec 8;16(6):487-9 [6]. Ni J，et al. Tyrosine receptor kinase B is a drug target in astrocytomas. Neuro Oncol. 2017 Jan;19(1):22-30. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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