{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > AfatinibCAS：850140-72-6
Molecular Formula：C24H25ClFN5O3
Molecular Weight：485.94
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 850140-72-6 |
| Name | Afatinib |
| Molecular Formula | C24H25ClFN5O3 |
| Molecular Weight | 485.94 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| MDL | MFCD12407405 |
| SMILES | O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)/C=C/CN(C)C.[(E)] |
| InChIKey | ULXXDDBFHOBEHA-CWDCEQMOSA-N |
| InChI | InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 |
| PubChem CID | 10184653 |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | Afatinib is an irreversible EGFR family inhibitor. |
| Biological Activity | Afatinib (BIBW 2992) 是不可逆的 EGFR 家族抑制剂, 抑制EGFRwt, EGFRL858R, EGFRL858R/T790M 和 HER2的 IC50 分别为0.5 nM, 0.4 nM, 10 nM 和 14 nM[1-4]。 |
| IC50 | EGFR:0.5nM (IC50) HER2:14nM (IC50) EGFRL858R:0.4nM (IC50) EGFRL858R/T790M:10nM (IC50) |
| Data Literature Source | [1]. Li D， et al. BIBW2992， an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7; 27 (34) :4702-11. [2]. Wong CH， et al. Preclinical evaluation of afatinib (BIBW2992) in esophageal squamous cell carcinoma (ESCC) . Am J Cancer Res. 2015 Nov 15; 5 (12) :3588-99. [3]. Wang XK， et al. Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo. Oncotarget. 2014 Dec 15; 5 (23) :11971-85. [4]. Yoshioka T， et al. Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer. Cancer Sci. 2018 Apr; 109 (4) :1166-1176. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
