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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > Montelukast SodiumCAS：151767-02-1
Molecular Formula：C35H35ClNNaO3S
Molecular Weight：608.17
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 151767-02-1 |
| Name | Montelukast Sodium |
| Molecular Formula | C35H35ClNNaO3S |
| Molecular Weight | 608.17 |
| Solubility | Soluble in DMSO ≥50mg/mL;Soluble in Wate ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| EC | EINECS 604-813-7 |
| MDL | MFCD00931431 |
| SMILES | ClC1=CC2=C(C=C1)C=CC(/C=C/C3=CC([C@H](SCC4(CC([O-])=O)CC4)CCC5=CC=CC=C5C(C)(O)C)=CC=C3)=N2.[Na+] |
| InChIKey | LBFBRXGCXUHRJY-HKHDRNBDSA-M |
| InChI | InChI=1S/C35H36ClNO3S.Na/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29;/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39);/q;+1/p-1/b15-10+;/t32-;/m1./s1 |
| PubChem CID | 23663996 |
| Target Point | Leukotriene Receptor |
| Passage | GPCR & G Protein |
| Background | Montelukast sodium is a potent, selective leukotriene receptor antagonist. |
| Biological Activity | Montelukast sodium是有效，选择性的白三烯受体受体拮抗剂。[1-4] |
| Data Literature Source | [1]. Mullol J，et al. Montelukast reduces eosinophilic inflammation by inhibiting both epithelial cell cytokine secretion (GM-CSF，IL-6，IL-8) and eosinophil survival. J Biol Regul Homeost Agents. 2010 Oct-Dec;24(4):403-11. [2]. Zhang HP，et al. Montelukast for prevention and treatment of asthma exacerbations in adults: Systematic review and meta-analysis. Allergy Asthma Proc. 2014 Jul-Aug;35(4):278-87. [3]. Wei B，et al. Effect of montelukast on the expression of neurokinin-1 receptor in young asthmatic rats with airway remodeling. Zhongguo Dang Dai Er Ke Za Zhi. 2013 Apr;15(4):298-301. [4]. Lai J，et al. Montelukast targeting the cysteinyl leukotriene receptor 1 ameliorates Aβ1-42-induced memory impairment and neuroinflammatory and apoptotic responses in mice. Neuropharmacology. 2014 Apr;79:707-14 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in Water 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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