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Purmorphamine

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Cat.No：IP1700 Solarbio

CAS：483367-10-8

Molecular Formula：C₃₁H₃₂N₆O₂

Molecular Weight：520.62

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥97%

Appearance：White to off-white Solid

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Product Information

CAS	483367-10-8
Name	Purmorphamine
Molecular Formula	C₃₁H₃₂N₆O₂
Molecular Weight	520.62
Solubility	Soluble in DMSO
Purity	≥97%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Delivery Time	1-2 Days
EC	EINECS 200-256-5
MDL	MFCD09037557
SMILES	N1(C2=CC=C(NC3=NC(OC4=CC=CC5=C4C=CC=C5)=NC6=C3N=CN6C7CCCCC7)C=C2)CCOCC1
InChIKey	FYBHCRQFSFYWPY-UHFFFAOYSA-N
InChI	InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
PubChem CID	5284329
Target Point	Hedgehog/Smoothened agonist
Passage	Hedgehog;Stem Cells
Background	Purmorphamine is a smooth receptor agonist.
Biological Activity	Purmorphamine是一种平滑受体激动剂，EC50为1 μM。[1-3]
IC50	1.5μM(Smoothened)
Data Literature Source	[1]. F. Faghihia，et al. The effect of purmorphamine and sirolimus on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Biomedicine & Pharmacotherapy. 2013，67(1): 31-38. [2]. Gu D，et al. A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis. J Biol Chem. 2012 Nov 2;287(45):38356-66. [3]. Beloti MM，et al. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol Int. 2005 Jul;29(7):537-41.
Unit	Piece
Specification	5mg 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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