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Baricitinib

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Cat.No：IB1000 Solarbio

CAS：1187594-09-7

Molecular Formula：C₁₆H₁₇N₇O₂S

Molecular Weight：371.42

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	1187594-09-7
Name	Baricitinib
Molecular Formula	C₁₆H₁₇N₇O₂S
Molecular Weight	371.42
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 691-421-4
MDL	MFCD27920779
SMILES	N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(S(=O)(CC)=O)C1
InChIKey	XUZMWHLSFXCVMG-UHFFFAOYSA-N
InChI	InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
PubChem CID	44205240
Target Point	JAK
Passage	JAK/STAT Signaling
Background	Baricitinib is a selective, JAK1 and JAK2 inhibitor.
Biological Activity	Baricitinib是选择性的 JAK1 和 JAK2 抑制剂, IC50 分别为5.9 nM 和 5.7 nM[1-3]。
IC50	JAK2:5.7nM (IC50) JAK1:5.9nM (IC50) Tyk2:53nM (IC50) JAK3:560nM (IC50) [1-3]
Data Literature Source	[1]. Fridman JS， et al. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol. 2010 May 1; 184 (9) :5298-307. [2]. Jabbari A， et al. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib. EBioMedicine. 2015 Feb 26; 2 (4) :351-5. [3]. Khan IM， et al. Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance. Int J Obes (Lond) . 2015 Nov; 39 (11) :1607-18
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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