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Valdecoxib

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Cat.No：IV0510 Solarbio

CAS：181695-72-7

Molecular Formula：C₁₆H₁₄N₂O₃S

Molecular Weight：314.36

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	181695-72-7
Name	Valdecoxib
Molecular Formula	C₁₆H₁₄N₂O₃S
Molecular Weight	314.36
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 448-010-8
MDL	MFCD00950568
SMILES	O=S(C1=CC=C(C2=C(C)ON=C2C3=CC=CC=C3)C=C1)(N)=O
InChIKey	LNPDTQAFDNKSHK-UHFFFAOYSA-N
InChI	InChI=1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20)
PubChem CID	119607
Target Point	COX
Passage	Immunology & Inflammation
Background	Valdecoxib is a potent and selective COX-2 inhibitor.
Biological Activity	Valdecoxib 是一种高效的，可口服的，选择性的 COX-2 抑制剂，对 COX-2 和 COX-1 的 IC50 值分别为 5 nM 和 140 μM，可用于关节炎和疼痛的研究。[1-3]
Data Literature Source	[1]. Talley JJ，et al. 4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide，valdecoxib: a potent and selective inhibitor of COX-2. J Med Chem. 2000 Mar 9;43(5):775-7. [2]. Wiktorowska-Owczarek A. The effect of valdecoxib on the production of growth factors evoked by hypoxia and bacterial lipopolysaccharide in HMEC-1 cells. Adv Clin Exp Med. 2013 Nov-Dec;22(6):795-800. [3]. Kumar A，et al. Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress. Neurosci Bull. 2010 Feb;26(1):17-27.
Unit	Bottle
Specification	10mg 10mM*1mL in DMSO 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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