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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > DinaciclibCAS：779353-01-4
Molecular Formula：C21H28N6O2
Molecular Weight：396.49
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to brown Solid
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| CAS | 779353-01-4 |
| Name | Dinaciclib |
| Molecular Formula | C21H28N6O2 |
| Molecular Weight | 396.49 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 214-589-6 |
| MDL | MFCD16037702 |
| SMILES | OCC[C@H]1N(CCCC1)C2=NC3=C(C=NN3C(NCC4=C[N+]([O-])=CC=C4)=C2)CC |
| InChIKey | PIMQWRZWLQKKBJ-SFHVURJKSA-N |
| InChI | InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1 |
| PubChem CID | 46926350 |
| Target Point | CDK |
| Passage | Cell Cycle |
| Background | Dinaciclib is a potent and selective CDK inhibitor. |
| Biological Activity | Dinaciclib 是一种有效的选择性 CDK 抑制剂，抑制 CDK2，CDK5，CDK1 和 CDK9 的 IC50 分别为 1，1，3 和 4 nM[1-3]。 |
| IC50 | CDK1:3nM;CDK2:1nM;CDK5:1nM;CDK9:4nM [1-3] |
| Data Literature Source | [1]. Parry D，et al. Dinaciclib (SCH 727965)，a novel and potent cyclin-dependent kinase inhibitor. Mol Cancer Ther. 2010 Aug;9(8):2344-53. [2]. Feldmann G，et al. Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models. Cancer Biol Ther. 2011 Oct 1;12(7):598-609. [3]. Feldmann G，et al. Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models. Cancer Biol Ther. 2011 Oct 1;12(7):598-609. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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