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Carfilzomib

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Cat.No：IC2020 Solarbio

CAS：868540-17-4

Molecular Formula：C₄₀H₅₇N₅O₇

Molecular Weight：719.91

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	868540-17-4
Name	Carfilzomib
Molecular Formula	C₄₀H₅₇N₅O₇
Molecular Weight	719.91
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 692-054-2
MDL	MFCD11040997
SMILES	C[C@@]1(C([C@H](CC(C)C)NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC(CN2CCOCC2)=O)CCC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)=O)=O)OC1
InChIKey	BLMPQMFVWMYDKT-NZTKNTHTSA-N
InChI	InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1
PubChem CID	11556711
Target Point	Proteasome
Passage	Metabolic Enzyme&Protease
Background	Carfilzomib is an irreversible proteasome inhibitor.
Biological Activity	Carfilzomib是不可逆的蛋白酶体 (proteasome) 抑制剂，其在ANBL-6和RPMI 8226细胞中的 IC50 为5 nM。[1-2]
Data Literature Source	[1]. Kuhn DJ，et al. Potent activity of carfilzomib，a novel，irreversible inhibitor of the ubiquitin-proteasome pathway，against preclinical models of multiple myeloma. Blood. 2007 Nov 1;110(9):3281-90. [2]. Dasmahapatra G，et al. Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo. Mol Cancer Ther. 2011 Sep;10(9):1686-97.
Unit	Bottle
Specification	5mg 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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