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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > BortezomibCAS：179324-69-7
Molecular Formula：C19H25BN4O4
Molecular Weight：384.24
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 179324-69-7 |
| Name | Bortezomib |
| Molecular Formula | C19H25BN4O4 |
| Molecular Weight | 384.24 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 605-854-3 |
| MDL | MFCD09056737 |
| SMILES | OB(O)[C@H](CC(C)C)NC([C@@H](NC(C1=NC=CN=C1)=O)CC2=CC=CC=C2)=O |
| InChIKey | GXJABQQUPOEUTA-RDJZCZTQSA-N |
| InChI | InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1 |
| PubChem CID | 387447 |
| Target Point | Proteasome |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a reversible and selective proteasome inhibitor that effectively inhibits the 20S proteasome by targeting threonine residues. Disrupts the cell cycle, induces apoptosis, and inhibits nuclear factor NF-κB. |
| Biological Activity | Bortezomib 是有效的 20S 蛋白酶体 (20S proteasome) 抑制剂，Ki 为 0.6 nM。[1-4] |
| IC50 | Ki: 0.6nM(20S proteasome)[1] |
| Data Literature Source | [1]. Adams J，et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999 Jun 1;59(11):2615-22. [2]. Boccadoro M，et al. Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. Cancer Cell Int. 2005 Jun 1;5(1):18. [3]. Yerlikaya A，et al. Combined effects of the proteasome inhibitor bortezomib and Hsp70 inhibitors on the B16F10 melanoma cell line. Mol Med Rep. 2010 Mar-Apr;3(2):333-9. [4]. Yamamoto S，et al. Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats. J Pharmacol Sci. 2015 Sep;129(1):43-50. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Fu Z, Lu C, Zhang C, Qiao B. Anticancer Drugs. 2019 Aug;30(7):e0773.
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PSMA5 promotes the tumorigenic process of prostate cancer and is related to bortezomib resistance
Click to check >>Author：Fu Z; Lu C; Zhang C; Qiao B
IF：0.0000
Publish_to：Anticancer Drugs
PMID：30807553
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