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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > AnacetrapibCAS：875446-37-0
Molecular Formula：C30H25F10NO3
Molecular Weight：637.51
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 875446-37-0 |
| Name | Anacetrapib |
| Molecular Formula | C30H25F10NO3 |
| Molecular Weight | 637.51 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1312995-182-4 |
| MDL | MFCD16294903 |
| SMILES | O=C1O[C@@H]([C@@H](N1CC2=CC(C(F)(F)F)=CC=C2C3=CC(C(C)C)=C(C=C3OC)F)C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4 |
| InChIKey | MZZLGJHLQGUVPN-HAWMADMCSA-N |
| InChI | InChI=1S/C30H25F10NO3/c1-14(2)22-11-23(25(43-4)12-24(22)31)21-6-5-18(28(32,33)34)9-17(21)13-41-15(3)26(44-27(41)42)16-7-19(29(35,36)37)10-20(8-16)30(38,39)40/h5-12,14-15,26H,13H2,1-4H3/t15-,26-/m0/s1 |
| PubChem CID | 11556427 |
| Target Point | CETP |
| Passage | Metabolic Enzyme&Protease |
| Background | Anacetrapib is a potent CETP inhibitor. |
| Biological Activity | Anacetrapib 是一种有效的 CETP 抑制剂，作用于 rhCETP 和 C13S CETP 突变型，IC50 分别为 7.9±2.5 nM 和 11.8±1.9 nM[1]。 |
| IC50 | 7.9±2.5nM(rhCETP)，11.8±1.9nM(CETPC13S)[1] |
| Data Literature Source | [1]. Niesor EJ，et al. Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport. J Lipid Res. 2010，51(12)，3443-3454. [2]. Dong B，et al. CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism. Atherosclerosis. 2014 Aug;235(2):449-62. [3]. Tan EY，et al. Pharmacokinetics，metabolism，and excretion of anacetrapib，a novel inhibitor of the cholesteryl ester transfer protein，in rats and rhesus monkeys. Drug Metab Dispos. 2010，38(3)，459-473. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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