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Amonafide

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Cat.No：IA1850 Solarbio

CAS：69408-81-7

Molecular Formula：C₁₆H₁₇N₃O₂

Molecular Weight：283.33

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥99%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	69408-81-7
Name	Amonafide
Molecular Formula	C₁₆H₁₇N₃O₂
Molecular Weight	283.33
Solubility	Soluble in DMSO
Purity	≥99%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00866438
SMILES	O=C1N(C(C2=CC(N)=CC3=CC=CC1=C23)=O)CCN(C)C
InChIKey	UPALIKSFLSVKIS-UHFFFAOYSA-N
InChI	InChI=1S/C16H17N3O2/c1-18(2)6-7-19-15(20)12-5-3-4-10-8-11(17)9-13(14(10)12)16(19)21/h3-5,8-9H,6-7,17H2,1-2H3
PubChem CID	50515
Target Point	Topoisomerase
Passage	DNA Damage/DNA Repair
Background	Amonafide is a topoisomerase II inhibitor and DNA intercalator, which induces apoptosis signaling by inhibiting the binding of Topo II to DNA.
Biological Activity	Amonafide 是一种Topoisomerase II 的抑制剂和 DNA 的嵌入剂，通过抑制 Topo II 与 DNA 的结合，来诱导凋亡信号通路的发生[1-3]。
Data Literature Source	[1]. Allen SL，et al. Amonafide: a potential role in treating acute myeloid leukemia. Expert Opin Investig Drugs. 2011 Jul;20(7):995-1003. [2]. Andersson BS，et al. In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia. Cancer Res. 1987 Feb 15;47(4):1040-4. [3]. Ajani JA，et al. In vitro activity of amonafide against primary human tumors compared with the activity of standard agents. Invest New Drugs. 1988 Jun;6(2):79-85.
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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