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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > BS-181 HClCAS：1397219-81-6
Molecular Formula：C22H33ClN6
Molecular Weight：416.99
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
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| CAS | 1397219-81-6 |
| Name | BS-181 HCl |
| Molecular Formula | C22H33ClN6 |
| Molecular Weight | 416.99 |
| Solubility | Soluble in Water |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18384975 |
| SMILES | CC(C1=C(N=C(C=C2NCC3=CC=CC=C3)NCCCCCCN)N2N=C1)C.[H]Cl |
| Target Point | CDK |
| Passage | Cell Cycle |
| Background | It is a potent and selective inhibitor of CDK7. |
| Biological Activity | BS-181 HCl是CDK7高效选择性抑制剂，IC50值21nM，对CDK1/92/4/5/6/9作用弱[1-2]。 |
| IC50 | CDK7/CycH/MAT1:0.021μM [1-2] |
| Data Literature Source | [1]. Ali S et al. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 2009 Aug 1;69(15):6208-15. [2]. Wang BY，et al. Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer. Drug Des Devel Ther. 2016 Mar 16;10:1181-9 |
| Unit | Bottle |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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