{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > AdavosertibCAS：955365-80-7
Molecular Formula：C27H32N8O2
Molecular Weight：500.6
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
Qty：
Size：
| CAS | 955365-80-7 |
| Name | Adavosertib |
| Molecular Formula | C27H32N8O2 |
| Molecular Weight | 500.6 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD17215200 |
| SMILES | O=C1N(N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)C)=NC=C21)C5=NC(C(O)(C)C)=CC=C5)CC=C |
| Target Point | Wee1 |
| Passage | Cell Cycle |
| Background | Adavosertib is a potent Wee1 inhibitor. |
| Biological Activity | Adavosertib (AZD-1775; MK-1775) 是一种有效的 Wee1 抑制剂, IC50 值为 5.2 nM[1-3]。 |
| IC50 | IC50: 5.2nM (Wee1) [1-3] |
| Data Literature Source | [1]. Hirai H， et al. MK-1775， a small molecule Wee1 inhibitor， enhances anti-tumor efficacy of various DNA-damaging agents， including 5-fluorouracil Cancer Biol Ther. 2010 Apr; 9 (7) :514-22. [2]. Bridges KA， et al. MK-1775， a novel Wee1 kinase inhibitor， radiosensitizes p53-defective human tumor cells. Clin Cancer Res. 2011 Sep 1; 17 (17) :5638-48. Epub 2011 Jul 28. [3]. Rajeshkumar NV， et al. MK-1775， a potent Wee1 inhibitor， synergizes with gemcitabine to achieve tumor regressions， selectively in p53-deficient pancreatic cancer xenografts.Clin Cancer Res. 2011 May 1; 17 (9) :2799-806. Epub 2011 Mar 9 |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
