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Gtenofovir

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Cat.No：IG1180 Solarbio

CAS：147127-20-6

Molecular Formula：C₉H₁₄N₅O₄P

Molecular Weight：287.21

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	147127-20-6
Name	Gtenofovir
Molecular Formula	C₉H₁₄N₅O₄P
Molecular Weight	287.21
Solubility	Soluble in Water/DMSO ≥5mg/mL
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 604-571-2
MDL	MFCD00943794
SMILES	C[C@@H](OCP(O)(O)=O)CN1C=NC2=C(N)N=CN=C12
Target Point	HIV;HBV
Passage	Anti-infection
Background	Tenofovir is a nucleotide reverse transcriptase inhibitor.
Biological Activity	Tenofovir 是一种用于治疗艾滋病毒和慢性乙型肝炎的核苷酸逆转录酶抑制剂。[1-4]
Data Literature Source	[1]. Murphy RA，et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18(3). [2]. Musumeci G，et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018. [3]. Wahl A，et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098. [4]. Menne S，Cote PJ，Korba BE，Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8
Unit	Bottle
Specification	50mg 10mM1mL in DMSO 10mM1mL in Water 100mg 500mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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