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AS-605240

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Cat.No：IA1920 Solarbio

CAS：648450-29-7

Molecular Formula：C₁₂H₇N₃O₂S

Molecular Weight：257.27

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Red to reddish brown Solid

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Product Information

CAS	648450-29-7
Name	AS-605240
Molecular Formula	C₁₂H₇N₃O₂S
Molecular Weight	257.27
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Red to reddish brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD11114066
SMILES	O=C(NC/1=O)SC1=C/C2=CC=C3N=CC=NC3=C2
Target Point	PI3Kγ
Passage	PI3K/Akt/mTOR
Background	AS-605240 is a specific PI3Kγ inhibitor.
Biological Activity	AS-605240 是一种有效的特异性 PI3Kγ 抑制剂，IC50 值为 8 nM，Ki 值为 7.8 nM[1-4]。
IC50	PI3Kα:60nM;PI3Kβ:270nM;PI3Kδ:300nM;PI3Kγ:8nM [1-4]
Data Literature Source	[1]. Huang X，et al. Endothelial p110γPI3K Mediates Endothelial Regeneration and Vascular Repair After Inflammatory Vascular Injury. Circulation. 2016 Mar 15;133(11):1093-103. [2]. Camps M，et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med. 2005 Sep;11(9):936-43. [3]. Azzi J，et al. The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes. Diabetes. 2012 Jun;61(6):1509-18. Epub 2012 Mar 8. [4]. Wei X，et al. A phosphoinositide 3-kinase-gamma inhibitor，AS605240 prevents bleomycin-induced pulmonary fibrosis in rats. Biochem Biophys Res Commun. 2010 Jun 25;397(2):311-7. Epub 2010 May 26.
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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