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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > VemurafenibCAS：918504-65-1
Molecular Formula：C23H18ClF2N3O3S
Molecular Weight：489.92
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 918504-65-1 |
| Name | Vemurafenib |
| Molecular Formula | C23H18ClF2N3O3S |
| Molecular Weight | 489.92 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18074504 |
| SMILES | FC1=CC=C(C(F)=C1C(C2=CNC3=NC=C(C=C32)C4=CC=C(C=C4)Cl)=O)NS(CCC)(=O)=O |
| Target Point | Raf |
| Passage | MAPK |
| Background | Vemurafenib is a potent B-RAF inhibitor. |
| Biological Activity | Vemurafenib 是有效的 B-RAF 抑制剂，能够抑制 RAFV600E 和 c-RAF-1 的活性，IC50 分别为 31 nM 和 48 nM。[1-3] |
| Data Literature Source | [1]. Bollag G，et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature，2010，467(7315)，596-599. [2]. Yang H，et al. RG7204 (PLX4032)，a selective BRAFV600E inhibitor，displays potent antitumor activity in preclinical melanoma models. Cancer Res，2010，70(13)，5518-5527. [3]. Prahallad A，et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature，2012，483(7387)，100-103 |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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