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Pelitinib

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Cat.No：IP1490 Solarbio

CAS：257933-82-7

Molecular Formula：C₂₄H₂₃ClFN₅O₂

Molecular Weight：467.92

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	257933-82-7
Name	Pelitinib
Molecular Formula	C₂₄H₂₃ClFN₅O₂
Molecular Weight	467.92
Solubility	Soluble in DMSO ≥1mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 803-625-4
MDL	MFCD09837868
SMILES	N#CC1=C(C2=CC(NC(/C=C/CN(C)C)=O)=C(OCC)C=C2N=C1)NC3=CC(Cl)=C(C=C3)F
Target Point	EGFR
Passage	Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling
Background	Pelitinib/EKB-569/WAY-EKB 569 are reversible EGFR inhibitors.
Biological Activity	Pelitinib 是可逆的 EGFR 抑制剂，IC50 值为38.5 nM。也可轻微抑制Src，MEK/ERK 和 ErbB2，IC50 值分别为282，800，和1255 nM。[1-2]
IC50	EGFR:38.5nM [1-2]
Data Literature Source	[1]. Torrance CJ，et al. Combinatorial chemoprevention of intestinal neoplasia. Nat Med. 2000 Sep;6(9):1024-8. [2]. Nunes M，et al. Phosphorylation of extracellular signal-regulated kinase 1 and 2，protein kinase B，and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor，EKB-569，in tumor cells and normal human keratinocytes. Mol Cancer Ther. 2004 Jan;3(1):21-7.
Unit	Bottle
Specification	5mg 25mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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