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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > PD173074CAS：219580-11-7
Molecular Formula：C28H41N7O3
Molecular Weight：523.67
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥95%
Appearance：Off-white to yellow Solid
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| CAS | 219580-11-7 |
| Name | PD173074 |
| Molecular Formula | C28H41N7O3 |
| Molecular Weight | 523.67 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥95% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD08705327 |
| SMILES | O=C(NC1=NC2=NC(NCCCCN(CC)CC)=NC=C2C=C1C3=CC(OC)=CC(OC)=C3)NC(C)(C)C |
| InChIKey | DXCUKNQANPLTEJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36) |
| PubChem CID | 1401 |
| Target Point | FGFR1;VEGFR2 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | PD173074 is a potent FGFR1 inhibitor; also inhibits VEGFR2 activity. |
| Biological Activity | PD173074 是有效的 FGFR1 抑制剂，IC50 为 25 nM；也可抑制 VEGFR2 的活性，IC50 值为 100-200 nM，对 FGFR1 的活性是 PDGFR 和 c-Src 的1000多倍。 |
| IC50 | FGFR1:25nM;VEGFR2:100nM [1-6] |
| Data Literature Source | [1]. Mohammadi M，et al. Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. EMBO J. 1998 Oct 15;17(20):5896-904. [2]. Skaper SD，et al. The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects. J Neurochem. 2000 Oct;75(4):1520-7. [3]. Bansal R，et al. Specific inhibitor of FGF receptor signaling: FGF-2-mediated effects on proliferation，differentiation，and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells. J Neurosci Res. 2003 Nov 15;74(4):486-93. [4]. Trudel S，et al. Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma. Blood. 2004 May 1;103(9):3521-8. [5]. Mahe M，et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Apr;10(4). pii: e8163. [6]. Zheng Y，et al. Inhibition of FGFR Signaling With PD173074 Ameliorates Monocrotaline-induced Pulmonary Arterial Hypertension and Rescues BMPR-II Expression. J Cardiovasc Pharmacol. 2015 Nov;66(5):504-14 |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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