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Daclatasvir

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Cat.No：ID1200 Solarbio

CAS：1009119-64-5

Molecular Formula：C₄₀H₅₀N₈O₆

Molecular Weight：738.88

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	1009119-64-5
Name	Daclatasvir
Molecular Formula	C₄₀H₅₀N₈O₆
Molecular Weight	738.88
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 1592732-453-0
MDL	MFCD17129086
SMILES	O=C([C@@H](NC(OC)=O)C(C)C)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C5=CN=C([C@@H]6CCCN6C([C@@H](NC(OC)=O)C(C)C)=O)N5)C=C4
Target Point	HCV Protease
Passage	Metabolic Enzyme/Protease
Background	Daclatasvir is a potent HCV NS5A inhibitor.
Biological Activity	Daclatasvir 是一种有效的 HCV NS5A 抑制剂，作用于基因型 1a 和 1b 复制子，平均 EC50 为 50 和 9 pM[1-3]。
Data Literature Source	[1]. Gao M，et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature. 2010 May 6;465(7294):96-100. [2]. Kai Y，et al. Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice. J Ga [3]. Zhang X，et al. Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism. Eur J Med Chem. 2018 Jan 1;143:1053-1065.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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