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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > LeflunomideCAS：75706-12-6
Molecular Formula：C12H9F3N2O2
Molecular Weight：270.21
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
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| CAS | 75706-12-6 |
| Name | Leflunomide |
| Molecular Formula | C12H9F3N2O2 |
| Molecular Weight | 270.21 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 616-254-6 |
| MDL | MFCD00867593 |
| SMILES | O=C(C1=C(C)ON=C1)NC2=CC=C(C(F)(F)F)C=C2 |
| InChIKey | VHOGYURTWQBHIL-UHFFFAOYSA-N |
| InChI | InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18) |
| PubChem CID | 3899 |
| Target Point | Dihydroorotate dehydrogenase |
| Passage | Metabolic Enzyme&Protease |
| Background | Leflunomide is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. |
| Biological Activity | Leflunomide 是一种嘧啶合成抑制剂，通过抑制二氢乳清酸脱氢酶 (dihydroorotate dehydrogenase) 起作用，具有抗风湿的作用。[1-3] |
| Data Literature Source | [1]. Davis JP，et al. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry. 1996 Jan 30;35(4):1270-3. [2]. Xu X，et al. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent，leflunomide. J Biol Chem. 1995 May 26;270(21):12398-403. [3]. Fox RI，et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec;93(3):198-208 |
| Unit | Bottle |
| Specification | 50mg 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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