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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > JNJ-7706621CAS：443797-96-4
Molecular Formula：C15H12F2N6O3S
Molecular Weight：394.36
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
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| CAS | 443797-96-4 |
| Name | JNJ-7706621 |
| Molecular Formula | C15H12F2N6O3S |
| Molecular Weight | 394.36 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11100270 |
| SMILES | O=S(C1=CC=C(NC2=NN(C(C3=C(F)C=CC=C3F)=O)C(N)=N2)C=C1)(N)=O |
| Target Point | Aurora Kinase;CDK |
| Passage | Cell Cycle |
| Background | JNJ-7706621 is a potent aurora kinase inhibitor, which potently inhibits both CDK1 and CDK2. |
| Biological Activity | JNJ-7706621 是一种有效的 aurora kinase 抑制剂，同时能有效抑制 CDK1 和 CDK2，对 CDK1，CDK2，Aurora-A 和 Aurora-B 的 IC50 值分别为 9，3，11 和 15 nM。[1-4] |
| Data Literature Source | [1]. Huang S，et al. Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3639-41. Epub 2006 May 6. [2]. Matsuhashi A，et al. Growth suppression and mitotic defect induced by JNJ-7706621，an inhibitor of cyclin-dependent kinases and aurora kinases. Curr Cancer Drug Targets. 2012 Jul;12(6):625-39. [3]. Danhier F，et al. Active and passive tumor targeting of a novel poorly soluble cyclin dependent kinase inhibitor，JNJ-7706621. Int J Pharm. 2010 Jun 15;392(1-2):20-8. [4]. Emanuel S，et al. The in vitro and in vivo effects of JNJ-7706621: a dual inhibitor of cyclin-dependent kinases and aurora kinases. Cancer Res. 2005 Oct 1;65(19):9038-46. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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