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GSK 1059615

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Cat.No：IG1170 Solarbio

CAS：958852-01-2

Molecular Formula：C₁₈H₁₁N₃O₂S

Molecular Weight：333.36

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to brown Solid

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Product Information

CAS	958852-01-2
Name	GSK 1059615
Molecular Formula	C₁₈H₁₁N₃O₂S
Molecular Weight	333.36
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD18074517
SMILES	O=C(S/C1=C\C2=CC=C3N=CC=C(C3=C2)C4=CC=NC=C4)NC1=O
Target Point	PI3K;mTOR
Passage	PI3K/Akt/mTOR
Background	GSK1059615 is a reversible inhibitor of PI3Kα/β/δ/γ, which also inhibits mTOR.
Biological Activity	GSK1059615 是 PI3Kα/β/δ/γ 可逆的抑制剂，同时也抑制 mTOR，IC50 值分别为 0.4 nM/0.6 nM/2 nM/5 nM 和 12 nM[1-3]。
IC50	PI3Kα:0.4nM;PI3Kβ:0.6nM;PI3Kδ:5nM;PI3Kγ:2nM;mTOR:12nM [1-3]
Data Literature Source	[1]. Carnero A. Novel inhibitors of the PI3K family. Expert Opin Investig Drugs. 2009 Sep;18(9):1265-77. [2]. Maira SM，et al. From the bench to the bed side: PI3K pathway inhibitors in clinical development. Curr Top Microbiol Immunol，2010，347，209-239. [3]. Takashi Kei Kishimoto，et al. Methods and compositions for attenuating gene therapy anti-viral transfer vector immune responses. US 20160074531 A1.
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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