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Epothilone B

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Cat.No：IE0780 Solarbio

CAS：152044-54-7

Molecular Formula：C₂₇H₄₁NO₆S

Molecular Weight：507.68

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	152044-54-7
Name	Epothilone B
Molecular Formula	C₂₇H₄₁NO₆S
Molecular Weight	507.68
Solubility	Soluble in DMSO ≥10mg/mL
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 604-822-6
MDL	MFCD02101921
SMILES	O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C[C@]3([H])O[C@]3(C)CCC[C@H](C)[C@H](O)[C@@H](C)C1=O
Target Point	Microtubule/Tubulin
Passage	Cytoskeleton
Background	Epothilone B is a microtubule stabilizer that acts by binding to the αβ-tubulin heterodimeric subunit, resulting in a reduction in αβ-tubulin dissociation.
Biological Activity	Epothilone B是微管稳定剂，Ki 为0.71 μM。它通过与αβ-微管蛋白异二聚体亚基结合而起作用，导致αβ-微管蛋白解离的减少[1-3]。
IC50	EC0.01: 1.8μM(Microtubule/Tubulin)[1]
Data Literature Source	[1]. Regueiro-Ren A，et al. Synthesis and biological activity of novel epothilone aziridines. Org Lett. 2001 Aug 23;3(17):2693-6. [2]. Pagano A，et al. Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends. Biochem Pharmacol. 2012 Aug 15;84(4):432-43. [3]. Oehler C，et al. The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells. Neuro Oncol. 2011 Sep;13(9):1000-10.
Unit	Bottle
Specification	2mg 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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