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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > Epothilone ACAS：152044-53-6
Molecular Formula：C26H39NO6S
Molecular Weight：493.66
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 152044-53-6 |
| Name | Epothilone A |
| Molecular Formula | C26H39NO6S |
| Molecular Weight | 493.66 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD26960884 |
| SMILES | O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C[C@]3([H])O[C@]3([H])CCC[C@H](C)[C@H](O)[C@@H](C)C1=O |
| Target Point | Microtubule/Tubulin |
| Passage | Cytoskeleton |
| Background | Epothilone A is a competitive inhibitor of paclitaxel and tubulin polymer binding. |
| Biological Activity | Epothilone A 是紫杉醇和管蛋白 (tubulin) 聚合物结合的竞争性抑制剂，其 Ki 值为 0.6-1.4 μM。[1-2] |
| Data Literature Source | [1]. Kowalski RJ，et al. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). J Biol Chem. 1997 Jan 24;272(4):2534-41. [2]. Cheng KL，et al. Novel microtubule-targeting agents - the epothilones. Biologics. 2008 Dec;2(4):789-811 |
| Unit | Bottle |
| Specification | 1mg 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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