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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > EnzalutamideCAS：915087-33-1
Molecular Formula：C21H16F4N4O2S
Molecular Weight：464.44
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 915087-33-1 |
| Name | Enzalutamide |
| Molecular Formula | C21H16F4N4O2S |
| Molecular Weight | 464.44 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 805-022-1 |
| MDL | MFCD14155804 |
| SMILES | S=C(N(C(C1(C)C)=O)C2=CC=C(C#N)C(C(F)(F)F)=C2)N1C3=CC(F)=C(C(NC)=O)C=C3 |
| Target Point | Androgen Receptor |
| Passage | Endocrinology & Hormones |
| Background | It is an androgen receptor (AR) antagonist. Can competitively inhibit the binding of androgen to the receptor, and can inhibit the nuclear transport of the androgen receptor and the interaction of the receptor with DNA. |
| Biological Activity | Enzalutamide (MDV3100) 是一种雄激素受体 (androgen receptor (AR) ) 拮抗剂, 在LNCaP前列腺细胞中抑制AR 的 IC50 值为36 nM[1]。 |
| IC50 | IC50: 36nM (androgen-receptor， in LNCaP cells) [1] |
| Data Literature Source | [1]. Tran C， et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science， 2009， 324 (5928) ， 787-790.; [2]. Scher HI， et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet， 2010， 375 (9724) ， 1437-1446.; [3]. Guerrero J， et al. Enzalutamide， an androgen receptor signaling inhibitor， induces tumor regression in a mouse model of castration-resistant prostate cancer. Prostate. 2013 Sep; 73 (12) :1291-305.; [3]. Guerrero J， et al. Enzalutamide， an androgen receptor signaling inhibitor， induces tumor regression in a mouse model of castration-resistant prostate cancer. Prostate. 2013 Sep; 73 (12) :1291-305.; ; ; ; |
| Unit | Bottle |
| Specification | 5mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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