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Tazarotene

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Cat.No：IT1490 Solarbio

CAS：118292-40-3

Molecular Formula：C₂₁H₂₁NO₂S

Molecular Weight：351.46

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	118292-40-3
Name	Tazarotene
Molecular Formula	C₂₁H₂₁NO₂S
Molecular Weight	351.46
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 601-516-4
MDL	MFCD00867628
SMILES	O=C(C1=CC=C(C#CC2=CC=C3C(C(C)(C)CCS3)=C2)N=C1)OCC
InChIKey	OGQICQVSFDPSEI-UHFFFAOYSA-N
InChI	InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3
PubChem CID	5381
Target Point	RAR
Passage	Metabolic Enzyme&Protease
Background	Tazarotene is a selective retinoic acid receptor (RAR) agonist.
Biological Activity	Tazarotene是选择性视黄酸受体 (RAR) 激动剂，用于治疗斑块状银屑病和寻常痤疮。[1-3]
Data Literature Source	[1]. Talpur R，et al. Efficacy and safety of topical tazarotene: a review. Expert Opin Drug Metab Toxicol. 2009 Feb;5(2):195-210. [2]. Nagpal S，et al. Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acidreceptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis. Cell Growth Differ. 1996 Dec;7(12):1783-91. [3]. Tang-Liu DD，et al. Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis. Clin Pharmacokinet. 1999 Oct;37(4):273-87.
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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