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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > SulfasalazineCAS：599-79-1
Molecular Formula：C18H14N4O5S
Molecular Weight：398.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to orange Solid
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| CAS | 599-79-1 |
| Name | Sulfasalazine |
| Molecular Formula | C18H14N4O5S |
| Molecular Weight | 398.39 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to orange Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 209-974-3 |
| MDL | MFCD00057363 |
| SMILES | OC(C1=C(O)C=CC(/N=N/C2=CC=C(S(=O)(NC3=NC=CC=C3)=O)C=C2)=C1)=O |
| InChIKey | NCEXYHBECQHGNR-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25) |
| PubChem CID | 5339 |
| Target Point | NF-κB; Autophagy; Apoptosis; Ferroptosis |
| Passage | NF-κB; Autophagy; Apoptosis |
| Background | Sulfasalazine is a potent, specific inhibitor of nuclear factor kappa B (NF-κB). Sulfasalazin can induce iron death, apoptosis and autophagy. |
| Biological Activity | Sulfasalazine是治疗类风湿关节炎和溃疡性结肠炎的药物。报道显示Sulfasalazine可抑制 NF-κB 的活性。[1-3] |
| Data Literature Source | [1]. Wahl C， et al. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J Clin Invest. 1998 Mar 1; 101 (5) :1163-74. [2]. Sykes L， et al. Sulfasalazine augments a pro-inflammatory response in interleukin-1β-stimulated amniocytes and myocytes. Immunology. 2015 Dec; 146 (4) :630-44. [3]. Chung WJ， et al. Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-kappaB. J Neurochem. 2009 Jul; 110 (1) :182-93 |
| Unit | Bottle |
| Specification | 500mg 10mM*1mL in DMSO 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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