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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Stem Cells > SemagacestatCAS：425386-60-3
Molecular Formula：C19H27N3O4
Molecular Weight：361.44
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 425386-60-3 |
| Name | Semagacestat |
| Molecular Formula | C19H27N3O4 |
| Molecular Weight | 361.44 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1592732-453-0 |
| MDL | MFCD25542369 |
| SMILES | O=C([C@H]1NC([C@@H](NC([C@H](C(C)C)O)=O)C)=O)N(CCC2=C1C=CC=C2)C |
| Target Point | Notch; -secretase |
| Passage | Stem Cells;Neuronal Signaling |
| Background | Semagacestat is a gamma-secretase inhibitor |
| Biological Activity | Semagacestat 是一种 γ-secretase 抑制剂，抑制 β-amyloid (Aβ42)，Aβ38 和 Aβ40，IC50 分别为 10.9，12 和 12.1 nM。也抑制 Notch，IC50 为 14.1 nM。[1-4] |
| IC50 | 10.9nM(Aβ42)，12nM(Aβ38)，12.1nM(Aβ40)，14.1nM(Notch)[1] |
| Data Literature Source | [1]. Mitani Y，et al. Differential effects between γ-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic mice. J Neurosci. 2012 Feb 8;32(6):2037-50. [2]. Elvang AB，et al. Differential effects of gamma-secretase and BACE1 inhibition on brain Abeta levels in vitro and in vivo. J Neurochem. 2009 Sep;110(5):1377-87. [3]. Justice NJ，et al. Posttraumatic stress disorder-like induction elevates β-amyloid levels，which directly activates corticotropin-releasing factor neurons to exacerbate stress responses. J Neurosci. 2015 Feb 11;35(6):2612-23. [4]. Portelius E，et al. Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs. J Alzheimers Dis. 2010;21(3):1005-12 |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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