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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > LumacaftorCAS：936727-05-8
Molecular Formula：C24H18F2N2O5
Molecular Weight：452.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 936727-05-8 |
| Name | Lumacaftor |
| Molecular Formula | C24H18F2N2O5 |
| Molecular Weight | 452.41 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16659051 |
| SMILES | FC1(F)OC(C=C(C=C2)C3(CC3)C(NC4=NC(C5=CC=CC(C(O)=O)=C5)=C(C=C4)C)=O)=C2O1 |
| Target Point | CFTR |
| Passage | Membrane Transporter&Ion Channel |
| Background | Lumacaftor is a CFTR regulator that corrects CFTR protein folding and trafficking. |
| Biological Activity | Lumacaftor (VX-809) 是 CFTR 调节剂, 可纠正 CFTR 蛋白的折叠和运输[1]。 |
| IC50 | EC50: 0.1μM (CFTR) [1] |
| Data Literature Source | [1]. Van Goor F， et al. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci U S A. 2011 Nov 15; 108 (46) :18843-8. [2]. Phuan PW， et al. Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy. Mol Pharmacol. 2014 Jul; 86 (1) :42-51 |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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