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RO4929097

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Cat.No：IR0550 Solarbio

CAS：847925-91-1

Molecular Formula：C₂₂H₂₀F₅N₃O₃

Molecular Weight：469.4

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	847925-91-1
Name	RO4929097
Molecular Formula	C₂₂H₂₀F₅N₃O₃
Molecular Weight	469.4
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD18384976
SMILES	O=C(C(C)(C(NCC(F)(C(F)(F)F)F)=O)C)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O
Target Point	Notch; -secretase
Passage	Stem Cells;Neuronal Signaling
Background	RO4929097 is a gamma secretase inhibitor.
Biological Activity	RO4929097 是一种 γ secretase 抑制剂，IC50 值为 4 nM，能够抑制细胞内 Aβ40 的产生和 Notch 活性，EC50 值分别为 14 nM 和 5 nM。RO4929097抑制ICN的产生，降低下游Notch靶标Hes1的表达。[1-3]
IC50	4nM(γ secretase)[1-3]
Data Literature Source	[1]. Luistro L，et al. Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties. Cancer Res. 2009，69(19)，7672-7680. [2]. Debeb BG，et al. Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells. Breast Cancer Res Treat. 2012. [3]. Huynh C，et al. The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma. PLoS One. 2011，6(9)，e25264
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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