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Pomalidomide

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Cat.No：IP1680 Solarbio

CAS：19171-19-8

Molecular Formula：C₁₃H₁₁N₃O₄

Molecular Weight：273.24

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	19171-19-8
Name	Pomalidomide
Molecular Formula	C₁₃H₁₁N₃O₄
Molecular Weight	273.24
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 805-902-5
MDL	MFCD12756407
SMILES	O=C1N(C(C2=C1C=CC=C2N)=O)C(C(N3)=O)CCC3=O
Target Point	TNF-α;E3 Ligase
Passage	Apoptosis;Ubiquitin
Background	Pomalidomide is an antiangiogenic and immunomodulatory agent.
Biological Activity	Pomalidomide (CC-4047)抑制LPS诱导的TNF-α释放，在PBMCs中IC50为13 nM。Pomalidomide 可以在PROTAC中用作靶向 E3 ligase 和抑制 E3 ligase protein cereblon (CRBN)。Pomalidomide可促进凋亡和细胞周期阻滞。[1-5]
IC50	13nM(TNF-α，in PBMCs)[1]
Data Literature Source	[1] Muller GW，et al. Bioorg Med Chem Lett，1999，9(11)，1625-1630. [2] Galustian C，et al. Cancer Immunol Immunother，2009，58(7)，1033-1045. [3] Schafer PH，et al. J Pharmacol Exp Ther，2003，305(3)，1222-1232. [4] Hernandez-Ilizaliturri FJ，et al. Clin Cancer Res，2005，11(16)，5984-5992. [5] Jing Lu，et al. Chem Biol . 2015 Jun 18;22(6):755-63.
Unit	Bottle
Specification	20mg 100mg 200mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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