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Pimobendan

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Cat.No：IP1670 Solarbio

CAS：74150-27-9

Molecular Formula：C₁₉H₁₈N₄O₂

Molecular Weight：334.37

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	74150-27-9
Name	Pimobendan
Molecular Formula	C₁₉H₁₈N₄O₂
Molecular Weight	334.37
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 640-420-7
MDL	MFCD00761648
SMILES	O=C1CC(C)C(C2=CC=C3N=C(C4=CC=C(OC)C=C4)NC3=C2)=NN1
InChIKey	GLBJJMFZWDBELO-UHFFFAOYSA-N
InChI	InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)
PubChem CID	4823
Target Point	Phosphodiesterase (PDE)
Passage	Metabolic Enzyme&Protease
Background	Pimobendan is a PDE3 selective inhibitor.
Biological Activity	Pimobendan (UD-CG115) is a selective inhibitor of PDE3 with IC50 of 0.32 μM[1-2].
IC50	PDE3[1].
Data Literature Source	[1]. Kajimoto K，et al. Contribution of phosphodiesterase isozymes to the regulation of the L-type calcium current in human cardiac myocytes. Br J Pharmacol. 1997 Aug;121(8):1549-56. [2]. Iwasaki A，et al. Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis. J Am Coll Cardiol. 1999 Apr;33(5):1400-7.
Unit	Bottle
Specification	5mg 25mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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