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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Palbociclib isethionateCAS：827022-33-3
Molecular Formula：C26H35N7O6S
Molecular Weight：573.66
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 827022-33-3 |
| Name | Palbociclib isethionate |
| Molecular Formula | C26H35N7O6S |
| Molecular Weight | 573.66 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 804-556-2 |
| MDL | MFCD22666589 |
| SMILES | CC(C1=C(N2C3CCCC3)N=C(NC4=NC=C(N5CCNCC5)C=C4)N=C1)=C(C(C)=O)C2=O.OCCS(O)(=O)=O |
| Target Point | CDK |
| Passage | Cell Cycle |
| Background | Palbociclib isethionate is a highly selective CDK4/6 inhibitor. |
| Biological Activity | Palbociclib isethionate是高选择性的 CDK4/6 抑制剂，IC50 为11 nM/16 nM[1-3]。 |
| IC50 | Cdk4/cyclin D3:9nM;Cdk4/cyclin D1:11nM;Cdk6/cyclin D2:16nM [1-3] |
| Data Literature Source | [1]. Fry DW，et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther，2004，3(11)，1427-1438. [2]. Baughn LB，et al. A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6. Cancer Res. 2006 Aug 1;66(15):7661-7. [3]. Finn RS，et al. PD 0332991，a selective cyclin D kinase 4/6 inhibitor，preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res. 2009;11(5):R77. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 10mM*1mL in Water 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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