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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > DoramapimodCAS：285983-48-4
Molecular Formula：C31H37N5O3
Molecular Weight：527.66
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
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| CAS | 285983-48-4 |
| Name | Doramapimod |
| Molecular Formula | C31H37N5O3 |
| Molecular Weight | 527.66 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1308068-626-2 |
| MDL | MFCD09752957 |
| SMILES | O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=C4C=CC=CC4=C(OCCN5CCOCC5)C=C3 |
| Target Point | p38 MAPK |
| Passage | MAPK |
| Background | Doramapimod is a potent p38α inhibitor |
| Biological Activity | Doramapimod 是一种高效的 p38α 抑制剂，IC50 为 4 nM，也抑制 B-Raf 和 Abl，IC50 分别为 83 nM 和 14.6 μM[1-5]。 |
| IC50 | IC50：83.4nM B-Raf);4nM(p38α);14600nM(Abl0)[1-5] |
| Data Literature Source | [1]. Dietrich J，et al. The design，synthesis，and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec，Nexavar，and BIRB-796. Bioorg Med Chem. 2010 Aug 1;18(15):5738-48 [2]. Pargellis C，et al. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat Struct Biol，2002，9(4)，268-272. [3]. Kuma Y，et al. BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. J Biol Chem，2005，280(20)，19472-19479. [4]. He D，et al. BIRB796，the inhibitor of p38 mitogen-activated protein kinase，enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cells. PLoS One. 2013;8(1):e54181. [5]. Park JK，et al. p38 mitogen-activated protein kinase inhibition ameliorates angiotensin II-induced target organ damage. Hypertension. 2007 Mar;49(3):481-9 |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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