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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > DapagliflozinCAS：461432-26-8
Molecular Formula：C21H25ClO6
Molecular Weight：408.87
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥97%
Appearance：White to yellow Solid
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| CAS | 461432-26-8 |
| Name | Dapagliflozin |
| Molecular Formula | C21H25ClO6 |
| Molecular Weight | 408.87 |
| Solubility | Soluble in DMSO ≥10mg/mL;Soluble in Ethanol ≥25mg/mL |
| Purity | HPLC≥97% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 639-683-0 |
| MDL | MFCD13182359 |
| SMILES | O[C@H]1[C@H](C2=CC(CC3=CC=C(OCC)C=C3)=C(Cl)C=C2)O[C@H](CO)[C@@H](O)[C@@H]1O |
| Target Point | SGLT |
| Passage | Membrane Transporter&Ion Channel |
| Background | Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. |
| Data Literature Source | [1]. Pedersen MG，et al. Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells. Sci Rep. 2016 Aug 18;6:31214. [2]. Yoon-Kyung Chang，et al. Dapagliflozin，SGLT2 Inhibitor，Attenuates Renal Ischemia-Reperfusion Injury. PLoS One. 2016; 11(7): e0158810. [3]. Chiba Y，et al. Dapagliflozin，a Sodium-Glucose Co-Transporter 2 Inhibitor，Acutely Reduces Energy Expenditure in BAT via Neural Signals in Mice. PLoS One. 2016 Mar 10;11(3):e0150756. [4]. Akahane K，et al. Efficacy of Mitiglinide Combined with Dapagliflozin in Streptozotocin-nicotinamide-induced Type 2 Diabetic Rats and in Zucker Fatty Rats. Drug Res (Stuttg). 2015 Aug;65(8):416-21. [5]. Sakaeda T，et al. Susceptibility to serious skin and subcutaneous tissue disorders and skin tissue distribution of sodium-dependent glucose co-transporter type 2 (SGLT2) inhibitors. Int J Med Sci. 2018 Jun 13;15(9):937-943. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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