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BMS 777607

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Cat.No：IB0980 Solarbio

CAS：1025720-94-8

Molecular Formula：C₂₅H₁₉ClF₂N₄O₄

Molecular Weight：512.89

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥99%

Appearance：White to off-white Solid

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Product Information

CAS	1025720-94-8
Name	BMS 777607
Molecular Formula	C₂₅H₁₉ClF₂N₄O₄
Molecular Weight	512.89
Solubility	Soluble in DMSO
Purity	≥99%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD16495773
SMILES	O=C(NC1=CC=C(C(F)=C1)OC2=C(C(N)=NC=C2)Cl)C3=C(C=CN(C3=O)C4=CC=C(C=C4)F)OCC
Target Point	c-Met/HGFR
Passage	Protein Tyrosine Kinase/RTK
Background	BMS 777607 is a Met-related inhibitor.
Biological Activity	BMS 777607 是一种 Met-related 抑制剂，能够抑制 c-Met，Axl，Ron 和 Tyro3 的活性，IC50 值为 3.9 nM，1.1 nM，1.8 nM 和 4.3 nM[1-3]。
IC50	3.9nM(c-Met)，1.1nM(Axl)，1.8nM(Ron)，4.3nM(Tyro3)[1-3]
Data Literature Source	[1]. Schroeder GM，et al. Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1，2-dihydropyridine-3-carboxamide (BMS-777607)，a selective and orally efficacious inhibitor of the Met kinase superfamily. J Med Ch [2]. Dai Y，et al. BMS-777607，a small-molecule met kinase inhibitor，suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro. Mol Cancer Ther，2010，9(6)，1554-1561. [3]. Dai Y，et al. Impact of the small molecule Met inhibitor BMS-777607 on the metastatic process in a rodent tumor model with constitutive c-Met activation. Clin Exp Metastasis，2012，29，253-261
Unit	Bottle
Specification	5mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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