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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > AZD 8055CAS：1009298-09-2
Molecular Formula：C25H31N5O4
Molecular Weight：465.54
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1009298-09-2 |
| Name | AZD 8055 |
| Molecular Formula | C25H31N5O4 |
| Molecular Weight | 465.54 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16660191 |
| SMILES | OCC1=CC(C2=NC3=NC(N4CCOC[C@@H]4C)=NC(N5[C@@H](C)COCC5)=C3C=C2)=CC=C1OC |
| Target Point | mTOR |
| Passage | PI3K/Akt/mTOR |
| Background | AZD-8055 is an ATP-competitive mTOR inhibitor. |
| Biological Activity | AZD-8055 是一种ATP竞争性的 mTOR 抑制剂，IC50 为 0.8 nM。AZD-8055 抑制 mTORC1 和 mTORC2。[1-3] |
| Data Literature Source | [1]. Chresta CM，et al. AZD8055 is a potent，selective，and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Res，2010，70(1)，288-298. [2]. You W，et al. Inhibition of mammalian target of rapamycin attenuates early brain injury through modulating microglial polarization after experimental subarachnoid hemorrhage in rats. J Neurol Sci. 2016 Aug 15;367:224-31. [3]. Kawata T，et al. Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T-cell leukemia. Cancer Sci. 2017 Oct 27. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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