{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > ApixabanCAS：503612-47-3
Molecular Formula：C25H25N5O4
Molecular Weight：459.5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥99%
Appearance：Off-white to yellow Solid
Qty：
Size：
| CAS | 503612-47-3 |
| Name | Apixaban |
| Molecular Formula | C25H25N5O4 |
| Molecular Weight | 459.5 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥99% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 639-684-6 |
| MDL | MFCD11977295 |
| SMILES | NC(C1=NN(C2=C1CCN(C2=O)C3=CC=C(C=C3)N4CCCCC4=O)C5=CC=C(C=C5)OC)=O |
| Target Point | Factor Xa |
| Passage | Metabolic Enzyme&Protease |
| Background | Apixaban is a highly selective, reversible Factor Xa inhibitor. |
| Biological Activity | Apixaban 是一种高度选择性的，可逆的 Factor Xa 抑制剂，抑制人和兔的 Factor Xa，Ki 值分别为 0.08 nM 和 0.17 nM。[1-4] |
| Data Literature Source | [1]. Pinto DJ，et al. Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4，5，6，7-tetrahydro-1H-pyrazolo[3，4-c]pyridine-3-carboxamide (apixaban，BMS-562247)，a highly potent，selective，efficacious，and orally bioavailable inhibitor of blo [2]. Wong PC，et al. Apixaban，an oral，direct and highly selective factor Xa inhibitor: in vitro，antithrombotic and antihemostatic studies. J Thromb Haemost. 2008 May;6(5):820-9. [3]. Zhang D，et al. Metabolism，pharmacokinetics and pharmacodynamics of the factor Xa inhibitor apixaban in rabbits. J Thromb Thrombolysis. 2010 Jan;29(1):70-80. [4]. He K，et al. Preclinical pharmacokinetics and pharmacodynamics of apixaban，a potent and selective factor Xa inhibitor. Eur J Drug Metab Pharmacokinet. 2011 Sep;36(3):129-39. |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
