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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > BafetinibCAS：859212-16-1
Molecular Formula：C30H31F3N8O
Molecular Weight：576.62
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：Light yellow to yellow Solid
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| CAS | 859212-16-1 |
| Name | Bafetinib |
| Molecular Formula | C30H31F3N8O |
| Molecular Weight | 576.62 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00008999 |
| SMILES | O=C(C1=CC=C(C(C(F)(F)F)=C1)CN2C[C@@H](N(C)C)CC2)NC3=CC=C(C)C(NC4=NC=CC(C5=CN=CN=C5)=N4)=C3 |
| Target Point | Bcr-Abl |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | Bafetinib is a Lyn/Bcr-Abl tyrosine kinase inhibitor. |
| Biological Activity | Bafetinib (INNO-406, NS-187) 是一种有效的，选择性的，双重Bcr-Abl/Lyn双重抑制剂，无细胞试验中IC50为5.8 nM/19 nM，对T315I突变型的磷酸化没有抑制作用，对PDGFR和c-Kit的作用效果较弱。[1-3] |
| IC50 | Abl:5.8nM(Cell-free assay);Lyn: 19nM(Cell-free assay)[1] |
| Data Literature Source | [1] Kimura S，et al. Blood. 2005，106(12)，3948-3954. [2] Kamitsuji Y，et al. Cell Death Differ. 2008，15(11)，1712-2172. [3] Yokota A，et al. Blood. 2007，109(1)，306-314. |
| Unit | Bottle |
| Specification | 5mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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