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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Stem Cells > AvagacestatCAS：1146699-66-2
Molecular Formula：C20H17ClF4N4O4S
Molecular Weight：520.88
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
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| CAS | 1146699-66-2 |
| Name | Avagacestat |
| Molecular Formula | C20H17ClF4N4O4S |
| Molecular Weight | 520.88 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD13195458 |
| SMILES | O=S(N([C@@H](C(N)=O)CCC(F)(F)F)CC1=CC=C(C2=NOC=N2)C=C1F)(C3=CC=C(Cl)C=C3)=O |
| Target Point | γ-secretase;Notch |
| Passage | Stem Cells;Neuronal Signaling |
| Background | Avagacestat is A potent gamma-secretase inhibitor that inhibits the production of Aβ42 and Aβ40. Notch intracellular domain (NICD) and CYP2C19 are also inhibited, which can be used in Alzheimers disease research. |
| Biological Activity | BMS-708163 是有效的 γ-secretase 抑制剂, 抑制 Aβ42 和 Aβ40 的产生, IC50 值分别为 0.27 nM 和 0.30 nM; BMS-708163 同时抑制 Notch 胞内结构域 (NICD) 和 CYP2C19, IC50 值分别为 0.84 nM 和 20 μM[1-4]。 |
| IC50 | IC50: 0.27nM (γ-secretase， Aβ42) ， 0.30nM (γ-secretase， Aβ40) ， 20μM (CYP2C19) [1]， 0.84nM (NICD) [2] |
| Data Literature Source | [1]. Gillman KW， et al. Letter Discovery and Evaluation of BMS-708163， a Potent， Selective and Orally Bioavailable γ-Secretase Inhibitor. Med Chem Lett， 2010， 1 (3) ， 120-124. [2]. Crump CJ， et al. BMS-708，163 targets presenilin and lacks notch-sparing activity. Biochemistry. 2012 Sep 18; 51 (37) :7209-11. [3]. Xie M， et al. γ Secretase inhibitor BMS-708163 reverses resistance to EGFR inhibitor via the PI3K/Akt pathway in lung cancer. J Cell Biochem. 2015 Jun; 116 (6) :1019-27. [4]. Borghys H， et al. A canine model to evaluate efficacy and safety of γ-secretase inhibitors and modulators. J Alzheimers Dis. 2012; 28 (4) :809-22. |
| Unit | Bottle |
| Specification | 5mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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