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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > YM-201636CAS：371942-69-7
Molecular Formula：C25H21N7O3
Molecular Weight：467.48
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to brown Solid
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| CAS | 371942-69-7 |
| Name | YM-201636 |
| Molecular Formula | C25H21N7O3 |
| Molecular Weight | 467.48 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16038303 |
| SMILES | O=C(NC1=CC=CC(C2=NC(N3CCOCC3)=C4OC5=NC=CC=C5C4=N2)=C1)C6=CC=C(N=C6)N |
| Target Point | PIKfyve |
| Passage | PI3K/Akt/mTOR |
| Background | YM-201636 is a potent and selective inhibitor of PIKfyve. YM-201636 also inhibits p110α. |
| Biological Activity | YM-201636 是高效选择性的 PIKfyve 抑制剂, IC50 值为 33 nM。YM-201636 也抑制 p110α, IC50 为 3.3 μM[1-4]。 |
| IC50 | PIKfyve:33nM (IC50) p110α:3.3μM (IC50) [1-4] |
| Data Literature Source | [1]. Jefferies HB， et al. A selective PIKfyve inhibitor blocks PtdIns (3，5) P (2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep， 2008， 9 (2) ， 164-170. [2]. Ikonomov OC， et al. YM-201636， an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns (3，5) P2 synthesis， halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8; 382 (3) :566-70. [3]. Sbrissa D， et al. Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns (3，5) P2 by means of the PIKfyve inhibitor YM-201636. Am J Physiol Cell Physiol. 2012 Aug 15; 303 (4) :C436-46. [4]. Dukes JD， et al. The PIKfyve inhibitor YM-201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS One. 2012; 7 (3) :e28659. |
| Unit | Bottle |
| Specification | 2mg 5mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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