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Tyrphostin AG 1024

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Cat.No：IT1360 Solarbio

CAS：65678-07-1

Molecular Formula：C₁₄H₁₃BrN₂O

Molecular Weight：305.17

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to yellow Solid

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Product Information

CAS	65678-07-1
Name	Tyrphostin AG 1024
Molecular Formula	C₁₄H₁₃BrN₂O
Molecular Weight	305.17
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD02179365
SMILES	N#C/C(C#N)=C\C1=CC(C(C)(C)C)=C(O)C(Br)=C1
InChIKey	ABBADGFSRBWENF-UHFFFAOYSA-N
InChI	InChI=1S/C14H13BrN2O/c1-14(2,3)11-5-9(4-10(7-16)8-17)6-12(15)13(11)18/h4-6,18H,1-3H3
PubChem CID	2044
Target Point	IGF-1R
Passage	Protein Tyrosine Kinase/RTK
Background	It inhibits IGF-1R autophosphorylation.
Biological Activity	AG-1024 抑制胰岛素类生长因子-1 (IGF-1) 和胰岛素刺激的细胞增殖，IC50分别为0.4 μM和 0.1 μM, 抑制IGF-1受体和胰岛素受体自磷酸化，IC50分别为7 μM 和57 μM,也抑制受体酪氨酸激酶作用于外源底物(TKA)的活性，IC50 分别为18 μM和 80 μM。[1]
Data Literature Source	[1] Párrizas M，et al. Endocrinology，1997，138(4)，1427-1433 [2] Wen B，et al. Br J Cancer，2001，85(12)，2017-2021. [3] von Willebrand M，et al. Cancer Res，2003，63(6)，1420-1429. [4] Deutsch E，et al. Br J Cancer，2004，91(9)，1735-1741.
Unit	Bottle
Specification	5mg 25mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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