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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Ubiquitin > ThalidomideCAS：50-35-1
Molecular Formula：C13H10N2O4
Molecular Weight：258.23
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 50-35-1 |
| Name | Thalidomide |
| Molecular Formula | C13H10N2O4 |
| Molecular Weight | 258.23 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-031-1 |
| MDL | MFCD00153873 |
| SMILES | O=C1N(C2CCC(NC2=O)=O)C(C3=CC=CC=C31)=O |
| InChIKey | UEJJHQNACJXSKW-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17) |
| PubChem CID | 5426 |
| Target Point | E3 Ligase |
| Passage | Ubiquitin |
| Background | Thalidomide inhibits ereblon and has immunomodulatory, anti-inflammatory, and antitumor activities. |
| Biological Activity | Thalidomide 最初是一种镇静剂，能够抑制 ereblon （cullin-4 E3 泛素连接酶复合物 CUL4-RBX1-DDB1 的一部分），Kd 值约为 250 nM，具有免疫调节、抗炎、抗肿瘤作用。[1-3] |
| IC50 | Kd: ～250nM(CRL4CRBN)[1] |
| Data Literature Source | [1]. Fischer ES，et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [2]. Bian C，et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453. [3]. Sun X，et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203. |
| Unit | Bottle |
| Specification | 200mg 500mg 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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