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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > TemozolomideCAS：85622-93-1
Molecular Formula：C6H6N6O2
Molecular Weight：194.15
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 85622-93-1 |
| Name | Temozolomide |
| Molecular Formula | C6H6N6O2 |
| Molecular Weight | 194.15 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 630-358-9 |
| MDL | MFCD00866492 |
| SMILES | O=C(C1=C(N2C=N1)N=NN(C)C2=O)N |
| InChIKey | BPEGJWRSRHCHSN-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13) |
| PubChem CID | 5394 |
| Target Point | Autophagy;DNA Alkylator/Crosslinker |
| Passage | Autophagy |
| Background | It is a DNA alkylating agent. It is also a pro-autophagy and pro-apoptosis agent. Has antitumor and antiangiogenic effects. |
| Biological Activity | Temozolomide (NSC 362856; CCRG 81045) 是可口服的用于治疗某些脑癌的DNA烷基化剂。[1-2] |
| Data Literature Source | [1]. Tentori L，et al. Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site. Blood. 2002 Mar 15;99(6):2241-4. [2]. Perazzoli G，et al. Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT，MMR，P-Glycoprotein and CD133 Expression. PLoS One. 2015 Oct 8;10(10):e0140131 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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