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Raltitrexed

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Cat.No：IR0470 Solarbio

CAS：112887-68-0

Molecular Formula：C₂₁H₂₂N₄O₆S

Molecular Weight：458.49

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥99%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	112887-68-0
Name	Raltitrexed
Molecular Formula	C₂₁H₂₂N₄O₆S
Molecular Weight	458.49
Solubility	Soluble in DMSO
Purity	≥99%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 652-997-2
MDL	MFCD00864168
SMILES	CC(NC1=O)=NC2=C1C=C(CN(C)C3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)S3)C=C2
Target Point	Thymidylate Synthase
Passage	Apoptosis
Background	It is a thymidine synthase inhibitor.
Biological Activity	Raltitrexed是一种用于化疗的抗代谢药物，通过抑制胸苷酸合成酶起作用。Raltitrexed阻断细胞周期在G0/G1期，线粒体膜电位降低。[1-4]
Data Literature Source	[1]. Zhao H，et al. Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest. Oncol Res. 2016;23(5):237-48 [2]. Dong Y，et al. Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage，apoptosis，and proliferation. Mol Cell Biochem. 2015 Jan;398(1-2):223-31. [3]. Xue S，et al. Raltitrexed induces mitochondrial-mediated apoptosis in SGC7901 human gastric cancer cells. Mol Med Rep. 2014 Oct;10(4):1927-34. [4]. Waldman BC，et al. Induction of intrachromosomal homologous recombination in human cells by raltitrexed，an inhibitor of thymidylate synthase. DNA Repair (Amst). 2008 Oct 1;7(10):1624-35.
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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